Defining the centromere

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Centromeres are the chromosomal domains at which the kinetochore, a protein complex required for the correct separation of chromosomes during mitosis and meiosis, is assembled. The incorporation of the histone variant CenH3 into centromeric nucleosomes is a prerequisite for the proper assembly and function of the kinetochore. A new study describes the chaperone protein NASPSIM3 and how it affects the depositioning of CenH3.